New LC Column Increases Retention for Acidic Compounds

GL Sciences recently released a new LC Column, the InertSustain AX-C18. It combines both an Anion Exchange Group with a Reversed Phase C18 group, resulting in a Mixed-Mode column. This column is the latest edition to the InertSustain Column line-up. The company’s in-house produced silica is used for the InertSustain AX-C18 column production. This guarantees the well-known stable batch-to-batch reproducibility as well as an excellent lifetime.

When analysing highly polar compounds, reversed phase columns are not always considered as an option. Not so long ago, reversed phase columns couldn’t handle a 100% water phase as eluent. Much has changed and GL Sciences introduced InertSustain AQ-C18 in 2015. This column was specifically designed to cope with a 100% water phase. Compared to a regular C18 column, it gives more retention to polar compounds. This improves your polar compounds chromatography, reducing the risk of overlapping peaks.

In 2018 GL Sciences released the InertSustain PFP column. Compared with the InertSustain AQ-C18 column, this column provides more retention for Basic Compounds. The recent released InertSustain AX-C18 column guarantees more retention for Acidic Compounds. Together, these 3 columns are a strong solution for HPLC Method Development of strong polar compounds.

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