Preparative

Turn Up The Heat And Go Green

Dec 22 2012

Author: Tony Edge, Monica Dolci, Luisa Pereira on behalf of Thermo Fisher Scientific (UK) Ltd

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The use of organic solvents in liquid chromatography is common; indeed trying to perform a separation with just an aqueous mobile phase in most laboratories is one that is not readily considered. Here we will discuss how a greener approach to separation science can be employed by raising the mobile phase temperature and decreasing or even eliminating the need for an organic solvent.  Other advantages associated with the use of temperature will also be discussed, in particular the selectivity changes that can occur as the temperature is varied.

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