• TRBP 'interacts with other biologically active substances' in RNA effects
    Biologically active substances which work with TRBP in its action on RNA have been studied


TRBP 'interacts with other biologically active substances' in RNA effects

Mar 02 2011

The RNA-binding protein TRBP has a number of other biologically active substances with which it interacts within the body, report researchers.

Analysis carried out using co-immunoprecipitation and mass spectrometry to identify the proteins involved has been published in Cell & Bioscience.

It was conducted by scientists working at the National Health Research Institutes of Taiwan, Eastern Virginia Medical School and National Institutes of Health in Maryland, USA.

They were able to characterise the biologically active substances involved in TRBP-driven processes like the RNA-induced silencing complex (RISC).

"Our findings provide a proteome of factors that may cooperate with TRBP in activities such as pre-microRNA processing and in RNA interference by the RISC complex," they write.

The identified proteins included some responsible for RNA modifications and processing, cell proliferation, DNA transcription and protein synthesis, among others.

Cell & Bioscience is the official periodical publication of the Society of Chinese Bioscientists in America.

Digital Edition

Chromatography Today - Buyers' Guide 2022

October 2023

In This Edition Modern & Practical Applications - Accelerating ADC Development with Mass Spectrometry - Implementing High-Resolution Ion Mobility into Peptide Mapping Workflows Chromatogr...

View all digital editions


EuCheMS Chemistry Congress

Jul 07 2024 Dublin, Ireland

HPLC 2024

Jul 20 2024 Denver, CO, USA

ICMGP 2024

Jul 21 2024 Cape Town, South Africa

ACS National Meeting - Fall 2024

Aug 18 2024 Denver, CO, USA

JASIS 2024

Sep 04 2024 Chiba, Tokyo, Japan

View all events