Fast and easy method development for large scale processes

Bioanalytical

Fast and easy method development for large scale processes

25 Jan, 2022

Published over 4 years ago. See the latest and most current information on Bioanalytical.

Before implementing large scale processes, the most straightforward approach is to develop and refine separation methods on a laboratory scale. Only then, risks and resource consumption can be kept on a bare-minimum. Also, it allows fast process modifications.

Self-packed glass columns are “the” lab tool for quick screenings due to two reasons:

  • any stationary phase available already in the lab can be chosen and
  • the packing is fast so that results are quickly obtained.

ECOPLUS columns as the perfect tool in method development

The approach has been successfully used in a recent study by Stefan Schmidt et al. They developed a brand-new method to purify mAb in large-scale production. Their approach was based on self-packed ECOPLUS glass columns.

The advantages are:

  • Low sample, resin and solvent consumption
  • High reproducibility
  • Easy column packing
  • Full biocompatibility for BioLC applications

You want to read more? Check out our Technical Note.

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