LC-MS
UHPLC Analysis of benzodiazepines and their metabolites by LC-MS/MS
Sep 24 2019
The analysis of benzodiazepines in biological fluids is important to clinicians and forensic toxicologists because of their sedative, hypnotic, antianxiety, antiepileptic and muscle relaxant properties. However, it is challenging to analyse these compounds because their chemical structures, molecular weights and fragmentation patterns during mass spectrometry are very similar.
This application note shows a high-resolution UHPLC separation using a robust YMC-Triart C18 column including the previous sample preparation. The simultaneous analysis of etizolam, triazolam, and their metabolites 8-ethylhydroxyetizolam, alpha-hydroxyetizolam, 4-hydroxytriazolam and alpha-hydroxytriazolam in biological samples is performed by MS/MS detection.
Digital Edition
Chromatography Today - Buyers' Guide 2022
December 2021
In This Edition Modern & Practocal Applications - Accelerating ADC Development with Mass Spectrometry - Implementing High-Resolution Ion Mobility into Peptide Mapping Workflows Chromatogr...
View all digital editions
Events
ACS National Meeting & Expo, Fall 2022
Aug 21 2022 Chicago, IL, USA & Online
Aug 22 2022 Frankfurt, Germany
Aug 27 2022 Maastricht, Netherlands
Aug 28 2022 Lisbon, Portugal
Sep 07 2022 Chiba, Japan