Maximising the benefits of Ion Chromatography Mass Spectrometry (IC-MS)

Metrohm enhances the benefits of the IC-MS method by integrating inline sample preparation for more convenience, higher throughput, and better reproducibility of results. A technical poster gives an overview of the many possible applications.

The Metrohm IC-MS method is dedicated to develop selective, sensitive, robust and accelerated applications for the detection of ions in matrix-loaded samples (e.g., soil, foodstuffs, biomass, fertilisers, polymers, salts, explosives, pharmaceuticals, plating baths). Only small sample volumes in the µL-range are required and trace detection is possible even in the presence of interfering matrix components.

Organic modifiers can be directly added to the eluent (up to 100%) to improve sample evaporation and MS-signals. For ultimate user convenience, the Metrohm IC and the Waters single quadrupoles are easily operated under the same software (Empower™ 3).

Automated Metrohm Inline Sample Preparation (MISP) techniques (e.g., Inline Ultrafiltration, Dilution, or Dialysis) protect the column, increase reproducibility of results, and minimise time required in the laboratory.

The method was used to determine:

• various small ions at trace-level concentrations such as fluoride, chloride, nitrite, bromide, nitrate, phosphate, and sulfate
• glyphosate and various other herbicides and their residues
• perchlorate at ultra-trace levels in various matrices
• oxoanions as well as thiosulfate and thiocyanate.

Find your IC-MS application in the Metrohm Application Finder.