• Maximising the benefits of Ion Chromatography Mass Spectrometry (IC-MS)

Ion chromatography (IC)

Maximising the benefits of Ion Chromatography Mass Spectrometry (IC-MS)

Metrohm enhances the benefits of the IC-MS method by integrating inline sample preparation for more convenience, higher throughput, and better reproducibility of results. A technical poster gives an overview of the many possible applications.

The Metrohm IC-MS method is dedicated to develop selective, sensitive, robust and accelerated applications for the detection of ions in matrix-loaded samples (e.g., soil, foodstuffs, biomass, fertilisers, polymers, salts, explosives, pharmaceuticals, plating baths). Only small sample volumes in the µL-range are required and trace detection is possible even in the presence of interfering matrix components.

Organic modifiers can be directly added to the eluent (up to 100%) to improve sample evaporation and MS-signals. For ultimate user convenience, the Metrohm IC and the Waters single quadrupoles are easily operated under the same software (Empower™ 3).

Automated Metrohm Inline Sample Preparation (MISP) techniques (e.g., Inline Ultrafiltration, Dilution, or Dialysis) protect the column, increase reproducibility of results, and minimise time required in the laboratory.

The method was used to determine:

  • various small ions at trace-level concentrations such as fluoride, chloride, nitrite, bromide, nitrate, phosphate, and sulfate
  • glyphosate and various other herbicides and their residues
  • perchlorate at ultra-trace levels in various matrices
  • oxoanions as well as thiosulfate and thiocyanate.

Find your IC-MS application in the Metrohm Application Finder.


Events

LabAsia 2025

Jul 14 2025 Kuala Lumpur, Malaylsia

SinS Solutions in Science

Jul 15 2025 Brighton, UK

ACS National Meeting - Fall 2025

Aug 17 2025 Washington DC, USA & Virtual

MC 2025

Aug 31 2025 Karlsruhe, Germany

CE Pharm 2025

Sep 07 2025 Rockville, MD

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