Preparative

In Search of a Generic Chiral Strategy: 101 Separations With One Method

Oct 14 2009

Author: Jim Thorn and John C. Hudson on behalf of Beckman Coulter Ltd

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In any approach to drug discovery, the challenges presented to the analytical chemist are compounded when a product contains one or more chiral centres. Enantiomers are stereoisomers that display chirality, having one or more asymmetric carbon centres, allowing them to exist as non-superimposable mirror images of one another. These isomers are difficult to analyze as they are both physically and chemically identical and differ only in the way they bend plane-polarized light and in their behaviour in a chiral environment.

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