7 µm Precision: The Ideal Particle Size for Challenging Purification Tasks

Selecting the appropriate particle size is a critical determinant of performance in preparative chromatography. With the particle size of 7 µm of YMC-Triart Prep C18-S, YMC offers a material specifically designed for demanding purification tasks – especially where high resolution, reproducibility, and chemical stability are essential.

This particle size combines the high efficiency typically associated with smaller particles with the robustness and lower backpressure of larger particles. It was engineered to deliver separations that unite analytical precision with preparative capability in an optimal way.

Outstanding Resolution for Complex Separation Challenges

The 7 µm particle reveals its full strength in the purification of structurally similar compounds. Its high efficiency enables accurate separation of isomers and closely related molecules, where conventional preparative materials often reach their limits.

YMC-Triart Prep C18-S with 7 µm also excels in the purification of peptides, oligonucleotides, and other molecules, which are notoriously difficult to separate due to similar hydrophobicities, secondary structures, or minimal chemical differences. The result: sharply defined peaks and excellent resolution, even for highly complex mixtures.

Hybrid Silica for Exceptional Chemical and Mechanical Stability

YMC-Triart Prep is built on an organic–inorganic hybrid silica matrix, providing exceptional chemical stability across a wide pH range (pH 2–10; up to pH 12 during CIP). In addition, the hybrid structure offers outstanding mechanical resilience.

This robustness significantly reduces particle abrasion and ensures consistent chromatographic behavior over many loading and cleaning cycles. As a result, YMC-Triart Prep is ideal for demanding purification processes where long-term reproducibility, high resolution, and stability are critical.

Flexible Use and Reliable Scalability

Thanks to the linear scalability within the YMC-Triart (Prep) product family, chromatographic behavior remains consistent across different particle sizes. This enables efficient method transfer and optimisation without extensive redevelopment efforts – an essential advantage in both process development and routine production.

Perfectly Matched with YMC-Actus and YMC-Actus SP

YMC-Triart Prep C18-S is available both as bulk material for self-packing and as pre-packed stainless-steel columns. When combined with YMC-Actus and YMC-Actus SP column hardware, it forms an ideal system for high-performance preparative purification.

• YMC-Actus utilises precise axial compression to ensure highly uniform packing and minimal dead volume.
• YMC-Actus SP incorporates dynamic spring-assisted axial compression, further enhancing packing homogeneity and long-term stability.

Together, these systems form a highly stable, reproducible setup tailored to preparative applications that demand efficiency, robustness, and process security.

Evaluate It Yourself – Experience the Advantages Firsthand

The 7 µm YMC-Triart Prep C18-S particle is the ideal choice for challenging separation tasks such as isomer separations, peptide purification, or the isolation of oligonucleotides. It combines excellent resolution with outstanding chemical and mechanical stability, offers maximum flexibility, and is available on short lead times.

Learn more in our detailed flyer – and discover how the 7 µm particle of YMC-Triart Prep can enhance your purification workflow.