• Optimizing Mobile Phase Solvent Purity for LC/MS

HPLC, UHPLC

Optimizing Mobile Phase Solvent Purity for LC/MS

Aug 15 2012

Thermo Fisher Scientific Inc., has published a white paper entitled “Optimizing mobile phase solvent purity for LC/MS.” Enhanced sensitivity and mass accuracy in liquid chromatography/mass spectroscopy (LC/MS) is essential when analytes are found in trace amounts. Purity is a crucial consideration when selecting appropriate solvents for use in such analyses, where background noise must be minimal. Optimizing the quality of mobile phase solvents can contribute to improving the chromatographic or mass spectroscopic properties of the analyte, as well as the overall detection limits of the instrument system. The whitepaper highlights the low mass background, metal ion content, contamination and LC/UV response, using diode array detection, that is possible when using the Fisher Chemical Optima LC/MS solvent range instead of other solvent brands.

Examining LC/MS solvents offered by seven companies, including Thermo Fisher, the white paper presents comparative chromatographic data from four different advanced LC/MS instruments. Data collected includes mass baseline, signal intensity, contamination by PEG and plasticizers, and metal ion content, all of which impact on the ease of MS interpretation. This data suggests that the Optima LC/MS solvent range is best for mobile phase purity.

Optima LC/MS solvents are manufactured and packaged using proprietary techniques to ensure exceptionally low metal ion content and minimal MS background noise. They also offer lot-to-lot consistency and extended column life due to low residue levels, setting the standard of excellence for consistent, reproducible performance in the mobile phase of advanced LC/MS systems.

The white paper can be downloaded at: http://www.thermo.com/eThermo/CMA/PDFs/Various/File_52953.pdf.
 


Digital Edition

Chromatography Today - Buyers' Guide 2022

October 2023

In This Edition Modern & Practical Applications - Accelerating ADC Development with Mass Spectrometry - Implementing High-Resolution Ion Mobility into Peptide Mapping Workflows Chromatogr...

View all digital editions

Events

NGVS 2024

May 23 2024 Beijing, China

Analiza

May 28 2024 Tel Aviv, Israel

HTC-18

May 28 2024 Leuven, Belgium

PREP 2024

May 28 2024 Philadelphia, PA, USA

CISILE 2024

May 29 2024 Beijing, China

View all events