Cogent Diamond Hydride™ HPLC columns provide unmatched performance for highly polar analytes through a silica hydride surface modified with <2% carbon, delivering precisely tuned hydrophobicity and exceptional selectivity.
Key Technical Advantages
- Engineered Surface Chemistry: Silica hydride base with minimal carbon improves retention and peak shape for amino acids, metabolites, carbohydrates, organic acids, and other very polar small molecules.
- High Matrix Compatibility: Performs reliably with plasma, urine, saliva, and other biologically complex samples.
- Reproducibility & Fast Equilibration: Short equilibration times and robust lot to lot consistency support high throughput LC MS workflows.
Method Development Benefits
- Enables separation of both polar and some non polar compounds within a single run, reducing instrument downtime and eliminating column switching.
- Compatible with LC MS friendly mobile phases (e.g., acetonitrile/formic acid), supporting sensitive detection and excellent repeatability.
Critical Usage Notes
- Purge prior mobile phases, flush injection ports, and equilibrate for 15–30 minutes before analysis.
- Use inline filters or guard columns when running “dirty” matrices or aggressive solvents.
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