• Biologically active substances 'are intimately associated'
    Intimate associations between biologically active substances hint at the mechanisms at play


Biologically active substances 'are intimately associated'

Jan 12 2011

A number of biologically active substances are "intimately associated" in a way that allows hypotheses to be made about their relationship with one another, say researchers.

Writing in Cell Communication and Signaling, Suresh Mishra, Sudharsana Ande and Neil Salter explain that phosphorylation in some proteins has been associated with beta-N-acetylglucosamine (O-GlcNAc) modification.

This in turn is mediated by the beta-N-acetylglucosamine transferase enzyme, adding to the interlinking between biologically active substances at play in the process.

While understanding of the mechanisms at work in O-GlcNAc modification is poor, the scientists propose that phosphorylation may in fact be a requisite part of the procedure.

This hypothesis is drawn from mass spectrometry analysis of O-GlcNAc modification sites in proteins conducted in recent years.

According to the scientists, their proposal facilitates understanding of how modification interplays with proteins' serine and threonine phosphorylation.

Cell Communication and Signaling addresses both translational and basic aspects of cellular mechanisms and is the official periodical of the Signal Transduction Society.

Digital Edition

Chromatography Today - Buyers' Guide 2022

December 2021

In This Edition Modern & Practocal Applications - Accelerating ADC Development with Mass Spectrometry - Implementing High-Resolution Ion Mobility into Peptide Mapping Workflows Chromatogr...

View all digital editions


Lab Asia 2023

Oct 10 2023 Hybrid event

MicroTAS 2023

Oct 15 2023 Katowice, Poland

ISPPP 2023

Nov 05 2023 Vienna, Austria

SETAC North America

Nov 12 2023 Louisville, KY, USA

Eastern Analytical Symposium

Nov 13 2023 Plainsboro, NJ, USA

View all events