Sign up now
Modern Chiral Separations using HPLC and SFC for Method Development and Prep Purification

Preparative

Modern Chiral Separations using HPLC and SFC for Method Development and Prep Purification

14 Oct, 2009

Published over 17 years ago. See the latest and most current information on Preparative.

Gary W. Yanik and Irene Tranquil
1 min read
Share on Facebook Share on LinkedIn Share on Twitter / X Share via Email
Download

This article discusses factors important to operating a fast (high throughput) and efficient HPLC/SFC method development and prep purification laboratory. Discussion will include procedures for quickly developing separation methods and purifying pharmaceutical candidates as well as the systems, instruments, columns, and solvents we use to develop methods and purify samples in one week. Select examples will be presented.

Latest Articles

High-Efficiency Preparative Imaged Capillary Isoelectric Focusing (iCIEF) and iCIEF-MS Protein Charge Variant Characterisation

Preparative

High-Efficiency Preparative Imaged Capillary Is...

12 min read

Imaged capillary isoelectric focusing (iCIEF) is a high throughput, highly efficient separation t...
The SFC Isolation and Purification of Cannabinoids using Application Specific Stationary Phases Under Optimised Conditions

Preparative

The SFC Isolation and Purification of Cannabino...

7 min read

Cannabis sativa is comprised of hundreds of individual compounds that can be classified in many c...
Development of a Cannabinoid Analysis within a Regulated Environment

Preparative

Development of a Cannabinoid Analysis within a...

8 min read

Interest in the therapeutic properties of organic compounds from cannabis such as cannabinoids ha...
Proteins Under Pressure

Preparative

Proteins Under Pressure

8 min read

Scientist’s understanding of the biological world has increased exponentially over the last few...
Accelerated Development of Quantitative Assays for Antibody Drug Conjugates

Preparative

Accelerated Development of Quantitative Assays...

11 min read

Antibody drug conjugates (ADCs) represent an exciting and rapidly growing class of biotherapeutic...
Method Development and Validation of Simultaneous Determination of Related Substances for Salmeterol Xinafoate and Fluticasone Propionate in Dry Powder Inhalers

Preparative

Method Development and Validation of Simultaneo...

11 min read

A simple, selective and precise reversed-phase high-performance liquid chromatography (RP-HPLC) m...
Injection by Extraction in Preparative SFC; Isolation of Impurities and Natural Products

Preparative

Injection by Extraction in Preparative SFC; Iso...

12 min read

Two applications of combined supercritical fluid extraction – supercritical fluid preparative c...
Sample Preparation Options for Aroma Analysis

Preparative

Sample Preparation Options for Aroma Analysis

9 min read

Following developments in Gas Chromatography (GC) instrumentation and data analysis software, the...
Evaluation of Columns, Temperatures and Pressures for Development and Optimization of SFC-FID for ASTM D6550

Preparative

Evaluation of Columns, Temperatures and Pressur...

8 min read

SFC has been well established for gasoline and diesel fuel analysis, using the ASTM D5186 [1] a...

Related Articles

HPLC, UHPLC

Electrostatic Effects in Hydrophilic Interaction Chromatography (HILIC): A Brief Review
Electrostatic Effects in Hydrophilic...
Arrow

GC, MDGC

Headspace Gas Chromatography as a Green Analytical Technique
Headspace Gas Chromatography as a Gre...
Arrow

Bioanalytical

Bioanalysis of Dermorphin, an Opioid Peptide in Equine Urine: Benefit of the VIP-Heated ESI Technology for the Quantitative Analysis of Thermally Labile Molecules
Bioanalysis of Dermorphin, an Opioid...
Arrow

GC, MDGC

The Value of Lean Sigma: Improving GC Processes in Pharmaceutical R&D
The Value of Lean Sigma: Improving GC...
Arrow

Explore Our Other Sites

Labmate Online
Recognition has not kept pace with influence, say laboratory professionals
Explore more Arrow
Envirotech Online
AI-linked digital twins could move environmental science from monitoring to prediction, researchers argue
Explore more Arrow
Pollution Solutions Online
Vacuum technology enables efficient lithium-ion battery recycling with recovery rates of up to 95%
Explore more Arrow
Petro Online
Fine-tuned language models outperform larger general-purpose AI on fuel property prediction
Explore more Arrow