Preparative
Published over 16 years ago. See the latest and most current information on Preparative.
Preparative High Performance Liquid Chromatography (prep HPLC) is an established technique that has been used extensively by the pharmaceutical and chemical industry for many different applications and stages of the product development process. From early discovery through to late stage clinical development and even production, preparative chromatography plays a very important role in bringing a product to marke
The drug discovery and development process is a lengthy one. After target selection and assay development, it can take between 10 and 15 years to complete, at a cost of $500 million to $1Billion dollars. Of the 5000 compounds studied during lead discovery and optimisation/selection, perhaps only 5 will make it to clinical trials. Therefore, the recent trend has been to study more compounds earlier in order to have more candidates to trial. This approach however, has resulted in a more lengthy timescale with respect to chemistry i.e. synthesis and purification.
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