Liquid chromatography
Continuous chromatography technology offers a powerful way to significantly improve process productivity while reducing operational costs and resource consumption. By optimising solvent usage, minimising waste streams, and increasing product yield, continuous LC processes contribute directly to more sustainable manufacturing – an aspect that is becoming increasingly important across the pharmaceutical and bioprocessing industries.
With YMC as your partner, you benefit from complete end-to-end solutions from a single source: continuous LC systems, advanced column technologies, and high-performance stationary phases that are perfectly matched for your application. The technology is suitable for a broad range of target molecules, from small molecules to complex biomolecules and viral particles.
In conventional preparative batch chromatography, achieving high purity often comes at the expense of yield because overlapping impurities force valuable product fractions to be discarded or reprocessed. Continuous chromatography technologies such as MCSGP (Multicolumn Countercurrent Solvent Gradient Purification) overcome this limitation through the automatic recycling of impure side fractions containing product.
By internally reusing these fractions, YMC’s continuous chromatography solutions significantly increase overall process efficiency and productivity while simultaneously reducing solvent consumption and material waste. This not only lowers production costs but also improves the environmental footprint of the purification process.
YMC’s highly efficient twin-column countercurrent technologies include advanced continuous chromatography modes such as CaptureSMB, MCSGP and N-Rich processes.
The YMC Contichrom CUBE is a flexible and scalable twin-column purification system designed for process development of small molecules and biotherapeutics including proteins, monoclonal antibodies, mRNA, peptides, and oligonucleotides. Its innovative dynamic process control and software allow users to operate batch, integrated batch, and continuous countercurrent purification processes within one platform.
The system is available as a 100-bar platform with 36 or 100 mL/min pumps and can be equipped with multi-wavelength detectors, large-capacity fraction collectors, and column thermostats.
Processes developed on the Contichrom CUBE can be seamlessly transferred to the Contichrom TWIN systems for manufacturing applications. These scalable systems support flow rates up to 2000 L/h and fulfil GMP manufacturing requirements.
Efficient continuous purification requires more than advanced instrumentation – it also depends on high-performance stationary phases and process resins. YMC provides a comprehensive portfolio of modern chromatographic materials optimised for continuous chromatography applications. The BioPro IEX series offers high-performance ion exchange media for biomolecules such as proteins, antibodies, peptides, and oligonucleotides. YMC-Triart Prep, based on innovative hybrid silica technology, combines outstanding mechanical strength with excellent pH stability, making it ideal for preparative RP purification of both small and large molecules. In addition, YMC supplies a wide range of preparative columns, including prepacked columns and robust reusable glass columns for self-packing or prepacked operation.
With YMC, customers receive perfectly coordinated systems, columns, and stationary phases from one experienced partner – enabling simplified workflows, reliable scalability, and efficient implementation of sustainable purification processes.
For more information about continuous chromatography and YMC’s complete purification solutions, please contact us directly.
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