• Quantitative analysis indicates hypoxia response of C elegans
    Gel electrophoresis allows quantitative analysis of hypoxic stress in C elegans

Electrophoretic Separations

Quantitative analysis indicates hypoxia response of C elegans

Sep 24 2010

Quantitative analysis using gel electrophoresis has revealed some of the mechanisms of the hypoxia response of the nematode Caenorhabditis elegans.

A study published in Proteome Science, which covers all aspects of structural and functional proteomics, notes the findings of a team of researchers from the Life Science College of Nanjing Agriculture University, Medical College of Yangzhou University and China's Fourth Military Medical University.

They used two-dimensional gel electrophoresis to examine proteomic maps of C elegans in hypoxic conditions and under control circumstances.

In their quantitative analysis, 19 protein spots were expressed differently depending on the oxygen levels available.

This could help to broaden researchers' understanding of hypoxic response, the team suggests, as the data indicates an important role of protein expression alterations in the reaction to oxygen deprivation in C elegans.

Of the 19 differentially expressed protein spots, nine were upregulated, while the remaining ten were downregulated during hypoxic stress periods.

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