Electrophoretic separations
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Scientists have used quantitative analysis processes to detect proteins associated with cancer.
In a study published by BMC Research Notes, a team from University of Sao Paulo, Brazil, noted that increased levels of S100A7 (Psoriasin), which is a small protein responsible for calcium-binding, is associated with the development of several types of cancer.
However, despite its close link, it has not yet been fully defined as a diagnostic or prognostic marker for cancer.
The team used quantitative analysis processes to produce a rabbit polyclonal antibody anti-rS100A7 protein which immunostaining generated little or no background staining in head and neck squamous cell carcinoma cells.
As a result of the investigation, the scientists suggested that the polyclonal anti-rS100A7 antibody generated in the study provides a good tool for the immunohistochemical detection of S100A7 protein.
The team also suggested that the antibody has potential uses for other tissue lesions aside from the human larynx squamous cell carcinoma and non-neoplastic larynx tested for and this should be further explored.
Posted by Neil Clark
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