• 'Promising tools' for quantitative analysis of CSF cancer biomarkers
    Electrophoresis is one promising tool for CSF cancer biomarker quantitative analysis

Electrophoretic Separations

'Promising tools' for quantitative analysis of CSF cancer biomarkers

Mar 04 2011

The quantitative analysis of biomarkers for cancer in the cerebrospinal fluid (CSF) has historically required a number of different techniques to be used in concert, researchers say.

Writing in Fluids and Barriers of the CNS, a periodical dedicated to disseminating research into health and disease in the central nervous system, the team from Penn State University list capillary electrophoresis and time-of-flight mass spectrometry among the new methods that may assist in the process.

Previous alternatives have included neuroimaging, neurological examination and cytology, each of which reportedly carries a lack of sensitivity when used in quantitative analysis of CSF cancer biomarkers.

"As systemic therapies for cancer improve, the CNS is becoming a more common site of disease recurrence," the scientists note.

By combining cell-based detection techniques with those systemic therapeutic agents, they suggest that multiple medical advantages may be achieved at once, while the CSF can be used as an early-warning system for the recurrence of cancer.

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