• Combined quantitative analysis holds promise for tumour proteins
    Detecting protein expression patterns in different tumour types can be achieved with multivariate quantitative analysis, according to Swedish researchers

Electrophoretic Separations

Combined quantitative analysis holds promise for tumour proteins

Sep 21 2010

Identifying common proteins in malignant tumours could be a matter of undertaking quantitative analysis using multiple variables, according to research published in BMC Bioinformatics.

Scientists from Sweden's Karolinska Institute and AstraZeneca's research and development facility in Sodertalje carried out multivariate testing on proteomics data obtained from tumours in the human colon and prostate.

They used existing data from two-dimensional gel electrophoresis to undertake quantitative analysis of proteins from different tumours in order to uncover any common patterns between them.

While previous research focusing on a single tumour type had not uncovered patterns in some proteins, the multivariate partial least squares approach adopted by the scientists was able to overcome this.

As a result, 14 proteins were identified for the two tumour types - colon and prostate - with matching patterns of differential expression in normal and malignant tissue.

BMC Bioinformatics carries peer-reviewed journal articles on novel statistical and computational approaches to analysing biological data.

Digital Edition

Chromatography Today - Buyers' Guide 2022

October 2023

In This Edition Modern & Practical Applications - Accelerating ADC Development with Mass Spectrometry - Implementing High-Resolution Ion Mobility into Peptide Mapping Workflows Chromatogr...

View all digital editions

Events

ACS National Meeting - Fall 2024

Aug 18 2024 Denver, CO, USA

JASIS 2024

Sep 04 2024 Chiba, Tokyo, Japan

BMSS-BSPR Super Meeting 2024

Sep 04 2024 University of Warwick, Coventry, UK

Mass Spectrometry 2024

Sep 10 2024 Rockville, MD, USA

Plastics Recycling World Expo Europe

Sep 11 2024 Brussels, Belgium

View all events