• SFC: A Greener Approach to Analytical and Purification Applications

Supercritical fluid (SFC), Green Chromatography

SFC: A Greener Approach to Analytical and Purification Applications

Jan 26 2012

For laboratories overwhelmed with solvent disposal and time-consuming solvent cleanup, supercritical fluid chromatography (SFC) is a beneficial alternative to purification and analytical applications. Considered a leading "green" purification technology, SFC systems from Waters are used to separate and isolate chiral and achiral chemical compounds using various methods of detection.

The principles of SFC are similar to those of liquid chromatography, however SFC typically uses carbon dioxide as the main mobile phase. SFC is essentially a normal-phase chromatographic technique with inherent high speed and efficiency due to its mobile phase. As a high pressure liquid, or supercritical fluid, using CO2 is a smart solvent for its low viscosity and high diffusivity needed in today's demanding purification labs and also a sustainable solvent as it is reused after being discarded from other industrial processes.

SFC excels at separating and purifying chiral compounds and natural products because it's faster, uses much less solvent, and overall is a less expensive and greener method that exceeds high pressure liquid chromatography (HPLC) in performance for chiral separations.

Whether you're just looking to analyze chiral compounds or need to purify those compounds, Waters has the solution that fits your needs.

ACQUITY UPSFC

The first UPLC-based SFC system that provides unprecedented advantages compared to normal phase HPLC. This approach for chiral and achiral separations minimizes harmful waste while gaining superior sensitivity, resolution, and speed.

Introducing the ACQUITY UPSFC System

Learn about Viridis SFC Columns

To speak to a Waters Representative, please contact 0208 238 6100 or email

uk@waters.com


Digital Edition

Chromatography Today - Buyers' Guide 2022

October 2023

In This Edition Modern & Practical Applications - Accelerating ADC Development with Mass Spectrometry - Implementing High-Resolution Ion Mobility into Peptide Mapping Workflows Chromatogr...

View all digital editions

Events

ACS National Meeting - Fall 2024

Aug 18 2024 Denver, CO, USA

JASIS 2024

Sep 04 2024 Chiba, Tokyo, Japan

BMSS-BSPR Super Meeting 2024

Sep 04 2024 University of Warwick, Coventry, UK

Mass Spectrometry 2024

Sep 10 2024 Rockville, MD, USA

Plastics Recycling World Expo Europe

Sep 11 2024 Brussels, Belgium

View all events