HPLC, UHPLC

  • Is There a Biomarker for Bipolar Disorder? - Chromatography Investigates

Is There a Biomarker for Bipolar Disorder? - Chromatography Investigates

Dec 10 2019 Read 1250 Times

Bipolar disorder is a mental illness that affects the moods of sufferers causing them to swing from extreme highs to depressive lows. People suffering from bipolar disorder have a high risk of continuing episodes of what are termed manic and depressive episodes. They also have an elevated risk of suicide and there is a chance of heritability of 60-80%.

It is reported in a recent paper that there has been a lack of systematic research into the underlying neurobiology as the illness progresses. A recent paper published in the journal Translational Psychiatry reports on how one team has used chromatography to investigate potential biomarkers for the illness and reports on how RNA damage might be a potential biomarker for bipolar disorder.

More than just mood swings

Many people have mood swings - anyone with a teenager in the house knows how hormone changes affect a person’s mood. But bipolar disorder is much more than the excitement or sullenness of a teenager with acne. People suffering from bipolar disorder suffer from extreme episodes of depression or mania that can last for several weeks or longer.

The extremes of bipolar disorder can affect the everyday life of sufferers - and approximately 1 in 100 people will be diagnosed with bipolar disorder at some point in their life. It often develops during the teenage years, particularly between 15 and 19. The pattern if episodes vary widely between people. The cause of bipolar disorder is unknown - although stress and genetic factors are thought to play a role.

Oxidative stress marker reveals itself to UHPLC

Research has previously suggested that elevated levels of oxidative stress markers are seen in some psychiatric disorders. Oxidative stress shows when there is an increase in certain oxidants which can lead to oxidative changes of cellular components - including DNA and RNA. One marker known as 8-oxo-7,8-dihydroguanosine (8-oxoGuo) is a marker for RNA oxidation and can be analysed in cerebrospinal fluid and urine using ultra-performance liquid-chromatography-mass spectrometry. Advances in the use of chromatography with mass spectrometry are discussed in the article, Recent Advances to Conquer Analytical Challenges with High-Resolution, Accurate Mass Spectrometry.

In the article referenced above, a team of researchers from Denmark analysed patients with bipolar disorder and healthy controls for levels of 8-oxoGuo and other markers using UHPLC-MS. The team found significantly raised levels of the marker in bipolar disorder patients than in the healthy controls and that the levels increased after episodes. They suggest that RNA damage might be a potential biomarker for bipolar disorder and that effective long-term preventive treatment may contribute to normalized life expectancy in BD

Reader comments

Do you like or dislike what you have read? Why not post a comment to tell others / the manufacturer and our Editor what you think. To leave comments please complete the form below. Providing the content is approved, your comment will be on screen in less than 24 hours. Leaving comments on product information and articles can assist with future editorial and article content. Post questions, thoughts or simply whether you like the content.

Post a Comment




Digital Edition

Chromatography Today - March 2020

March 2020

In This Edition Articles - Elimination of the Sample Solvent Effect when Analysing Water Solutions of Basic Peptides by HILIC - Method Development and Validation of Simultaneous Determinatio...

View all digital editions

Events

ASMS Conference

May 31 2020 Houston, TX, USA

PREP 2020 - EVENT CANCELLED

May 31 2020 Baltimore, MD, USA

ISMM 2020

Jun 07 2020 Taipei, Taiwan

HPLC 2020

Jun 20 2020 San Diego, CA, USA

IMSC 2020

Aug 29 2020 Rio de Janeiro, Brazil

View all events