GC, MDGC
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The effect of Vasoactive Intestinal Peptide (VIP) on asthma has been studied in order to shed light on any potential treatments.
In a report published by BMC Immunology journal, a team from the SUNY Stony Brook School of Medicine in the US noted that previous investigations had identified a number of unusual features of asthma in Vasoactive Intestinal Peptide knockout mice (VIP KO).
They found that there was peribronchiolar airway inflammation, with accumulation of lymphocytes and eosinophils, some pro-inflammatory cytokine production and airway hyper-responsiveness to inhaled methacholine.
Using mass chromatography processes, the team sought to examine the role of VIP in modulating anti-oxidant genes and their proteins, including lung carbonyl reductase.
Four male VIP KO mice and four wild-type age- and gender-matched mice were examined and it was found that a novel variant of anti-oxidant protein lung carbonyl reductase (car3) was uniquely and markedly elevated in the VIP KO mice.
The findings suggest that VIP influences the endogenous oxidant/antioxidant balance and may mean that it could be used as a treatment for inflammatory diseases.
Posted by Neil Clark
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