• Affinity chromatography 'must eliminate indirect processes'
    Indirect links must be eliminated from affinity chromatography results sets

Solid Phase Extraction (SPE)

Affinity chromatography 'must eliminate indirect processes'

Nov 01 2010

Affinity chromatography - which studies samples based on known interactions between an enzyme and substrate, or a protein and receptor - faces a need to distinguish between direct and indirect processes, say researchers.

Scientists at McGill University in Quebec and Cornell University in New York explain that the direct link between, for example, an enzyme and substrate may be disguised in findings by indirect processes at work in the same sample.

Writing in Algorithms for Molecular Biology, they have devised a way to examine the results for direct and indirect affiliations, in order to cleanse the data set of indirect - and therefore unwanted - influences.

Their algorithm filters out weakly connected nodes and estimates the direct interactions in dense regions of the results network, reconstructing the desired data with high specificity and sensitivity.

Algorithms for Molecular Biology specialises in research findings and innovations in the fields of biological sequencing, phylogeny reconstruction, machine learning and structural analysis.

Digital Edition

Chromatography Today - Buyers' Guide 2022

December 2021

In This Edition Modern & Practocal Applications - Accelerating ADC Development with Mass Spectrometry - Implementing High-Resolution Ion Mobility into Peptide Mapping Workflows Chromatogr...

View all digital editions


ASMS Conference

Jun 04 2023 Houston, TX, USA

Plastics Recycling World Expo Europe

Jun 14 2023 Essen, Germany

HPLC 2023

Jun 18 2023 Dusseldorf, Germany


Jul 04 2023 Cardiff, UK

Water Expo Nigeria 2023

Jul 11 2023 Lagos, Nigeria

View all events