• Quantitative analysis hints at biological cost of rifampicin resistance in N meningitidis
    Quantitative analysis of meningococcus proteins suggest drug-resistant strains spread less easily

Electrophoretic Separations

Quantitative analysis hints at biological cost of rifampicin resistance in N meningitidis

Sep 27 2010

Neisseria meningitidis has been examined using quantitative analysis through both two-dimensional electrophoresis and mass spectrometry to determine the impact of resistance to the drug rifampicin on its ability to spread.

According to researchers from Italy's Istituto Superiore di Sanita and the Sapienza University of Rome, drug resistance has long been suggested as having a biological cost associated with it.

Through this, they suggest in BMC Microbiology that some strains of virus can be resistant to treatment, yet less likely to spread throughout the general population than their non-resistant counterparts.

In quantitative analysis of N meningitidis, the scientists found 23 differently expressed proteins in resistant strains, compared with the normal population.

With multiple differently express proteins impacting on metabolism, they argue that the ability of a given strain to penetrate the population may be impaired.

BMC Microbiology covers research into micro-organisms, parasites and viruses associated with the spread of infectious disease.

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