Solid Phase Extraction (SPE)

Enabling facile, rapid and successful chromatographic Flash purification

Dec 22 2009

Author: Stéphane Dubant and Ben Mathews on behalf of Unassigned Independent Article

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Flash liquid chromatography (Flash-LC) is an established technique that can have a very positive impact on productivity in the pharmaceutical research and development chemistry laboratory - provided it is used efficiently. Finding the optimal conditions for a normal phase or reverse phase Flash-LC separation can be a laborious process. The aim of this work was to develop a screening system to enable automated, rapid and reliable method development for preparative Flash chromatography. Implementation of these method screening systems into the chemists workflow has had beneficial productivity and quality impacts at different stages of drug development, and on scales ranging from laboratory to pilot plant.

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