Reversed phase chromatography used to identify cancer-fighting agent
Reversed phase chromatography identifies Fusarisetin agent

HPLC, UHPLC

Reversed phase chromatography used to identify cancer-fighting agent

28 Apr, 2011

Published over 15 years ago. See the latest and most current information on HPLC, UHPLC.

Scientists in South Korea have used reversed phase chromatography to find a new anti-metastatic agent capable of fighting cancerous cells.

A team of experts led by Dr Jong Seog Ahn from the Korea Research Institute of Bioscience and Biotechnology (KRIBB) identified Fusarisetin after examining a fungus found in Korean soil with the help of a 3D cancer cell culture assay system.

The novel compound has a unique carbon skeletal backbone structure that is unlike anything else in nature and, as it displays no cell toxicity, boasts anti-metastatic properties suitable for working against cancer.

Its operational mechanism also suggests that it may offer new potential in uncovering novel targets for cancer drugs.

The team used flash reversed-phase column chromatography in their work, according to the Yonhap News Agency.

Speaking to the news provider, Dr Ahn said: "Cancer usually kills because it spreads throughout the body, but the new material shows promise of hindering such developments."

KRIBB's scientists conduct a variety of research in the fields of bionanotechnology, ageing, the brain, biomonitoring and integrative omics.

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