Manufacturer-Packed HPLC Columns for Every Application

MACHEREY-NAGEL, a pioneer in chromatography, introduced NUCLEOSIL^® HPLC columns into the market more than 40 years ago. The spherical NUCLEOSIL^® silica is still exclusively manufactured by MN. The columns are often used in quality control around the globe for validated methods. Only manufacturer-packed NUCLEOSIL^® columns are still available from MACHEREY-NAGEL and authorised distributors.

For nearly 15 years, they have supplemented their successful NUCLEOSIL^® column range by columns packed with the fully synthetical silica NUCLEODUR^® – a state-of-the-art silica for professional solutions. Several different surface modifications have been developed over the last years providing a full range of specified HPLC phases. Surface deactivated phases (e.g., C₁₈ Gravity-SB, C₁₈ Pyramid, Sphinx RP, Phenyl-Hexyl, PFP) are well-suitable for separations of basic and acidic analytes with high peak symmetry. C₁₈ ec and C₈ ec modifications with a pore size of 110 Å are modern standard phases for low molecular analytes – C₁₈ ec and C₄ ec with 300 Å for proteins and peptides. NUCLEODUR^® C₁₈ HTec is the preferred phase for preparative HPLC.

A few years ago, MACHEREY-NAGEL introduced NUCLEOSHELL^® columns packed with a superficially porous silica for highest efficiency in HPLC. The core-shell phases RP 18, RP 18plus, Phenyl-Hexyl, PFP, and HILIC are offered with the highly efficient particle size of 2.7 µm. Especially for an allowed transfer of Pharmacopoeia methods, the important modifications NUCLEOSHELL^® RP 18 and more polar RP 18plus are also available with the particle size of 5 µm.

For further information visit: www.mn-net.com/HPLC