HPLC Columns – Packed by the Sorbent Manufacturer

MACHEREY-NAGEL, manufacturer of chromatography sorbents, developed the HPLC sorbent NUCLEOSIL^® more than 40 years ago. It was one of the first spherical type A silicas and is still manufactured by MACHEREY-NAGEL. It comes in numerous modifications, particle and pore sizes. Manufacturer-packed HPLC columns are available with nonpolar RP phases (e.g., C₁₈, C₁₈ HD, C₈, C₆H₅) and polar phases (e.g., CN, NH₂, SA, SB, SiOH). They are often applied in validated methods.

For nearly 15 years, they have supplemented their successful NUCLEOSIL^® product range with the fully synthetical type B silica NUCLEODUR^® – a state-of-the-art silica for professional solutions. Several different surface modifications have been developed over the last years providing a full range of specified HPLC phases (e.g., C₈ and C₁₈ Gravity, C₁₈ Isis, C₁₈ Pyramid, PolarTec, Phenyl-Hexyl, Sphinx RP, PFP, HILIC). The recently launched NUCLEODUR^® C₁₈ Gravity-SB features hydrophobic and polar selectivity for a better retention of early eluting analytes.

With the NUCLEOSHELL^® core-shell particle technology MACHEREY-NAGEL introduced a superficially porous silica for highest efficiency in HPLC. Besides the C₁₈ modifications RP 18 and RP 18plus, innovative chemistries such as Phenyl-Hexyl, PFP, and HILIC are available. NUCLEOSHELL^® columns fulfill the high demands in research and quality control.

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