• Profiling of biologically active substances holds promise for PRRSV
    Biologically active substances analysed in China could hold research potential for PRRSV

Bioanalytical

Profiling of biologically active substances holds promise for PRRSV

Sep 22 2010

Porcine reproductive and respiratory syndrome virus (PRRSV) may be affected by individual biologically active substances that occur within its cellular structure, according to researchers.

Studies at Sun Yat-sen University, Guangdong Academy of Agricultural Sciences and South China Agricultural University, all located in Guangzhou, looked at the cellular proteins associated with the membranes of the PRRSV virions.

Gel electrophoresis and mass spectrometry were used to identify a total of 61 proteins, classified into eight categories according to function.

Among the classifications were cytoskeletal proteins, macromolecular biosynthesis, chaperones, metabolism-associated proteins and membrane binders dependent on calcium.

Based on their analysis of the biologically active substances, the scientists claim to have demonstrated how cellular proteins are incorporated into PRRSV virions, leading to potential pathways for further investigation of replication, assembly and pathogenesis of the virus.

The research is published in Virology Journal, an open-access periodical which accepts studies on all aspects of the discipline.

Digital Edition

Chromatography Today - Buyers' Guide 2022

October 2023

In This Edition Modern & Practical Applications - Accelerating ADC Development with Mass Spectrometry - Implementing High-Resolution Ion Mobility into Peptide Mapping Workflows Chromatogr...

View all digital editions

Events

NGVS 2024

May 23 2024 Beijing, China

Analiza

May 28 2024 Tel Aviv, Israel

HTC-18

May 28 2024 Leuven, Belgium

PREP 2024

May 28 2024 Philadelphia, PA, USA

CISILE 2024

May 29 2024 Beijing, China

View all events