• Scientists deepen their understanding of nasopharyngeal carcinoma
    Team analysed EGFR signalling pathway in nasopharyngeal carcinoma cells through phosphoproteomics.

Electrophoretic Separations

Scientists deepen their understanding of nasopharyngeal carcinoma

Jun 29 2011

Quantitative analysis of epidermal growth factor receptor (EGFR) signalling pathways has provided insight into cancer, possibly leading to future therapy development.

The EGFR is usually overexpressed in nasopharyngeal carcinoma (NPC), which is the most common type of cancer in the nasopharynx, the uppermost region of the pharynx or respiratory tract.

Overexpression of EGFR is associated with the development of the cancer, but little is understood about the downstream signalling proteins, so a study, published in Proteome Science, aimed to discover more through quantitative analysis.

The results revealed that phosphoprotein GSTP1 could contribute to paclitaxel resistance in epidermal growth factor (EGF)-stimulated CNE2 cells.

Scientists then constructed an EGFR signalling network based on the identified EGFR-regulated phosphoproteins using Pathway Studio 5.0 software, predicting that it includes novel EGFR-regulated proteins and implicates the possible biological roles for those proteins.

As a result, the team found information that would be useful to NPC pathogenesis and the development of therapeutic targets. 

Digital Edition

Chromatography Today - Buyers' Guide 2022

October 2023

In This Edition Modern & Practical Applications - Accelerating ADC Development with Mass Spectrometry - Implementing High-Resolution Ion Mobility into Peptide Mapping Workflows Chromatogr...

View all digital editions

Events

NGVS 2024

May 23 2024 Beijing, China

Analiza

May 28 2024 Tel Aviv, Israel

HTC-18

May 28 2024 Leuven, Belgium

PREP 2024

May 28 2024 Philadelphia, PA, USA

CISILE 2024

May 29 2024 Beijing, China

View all events