• Identification of human colorectal cancer proteins

Electrophoretic Separations

Identification of human colorectal cancer proteins

Dec 08 2011

Scientists have identified a number of proteins that are differently expressed in the presence of human colorectal cancer.

Published in the BMC Cancer journal, the team from Spain noted that the universal hallmark of cancer cells is a change in their glycosylation phenotype, with the enhancement of alpha(1,6) linked fucose residues of glycoproteins the most commonly seen pattern.

In the study, the team used LCA-affinity chromatography with SDS-PAGE and mass spectrometry to identify the proteins that are differently expressed in colorectal cancer.

The scientists found that there was an increased expression of GRP94 in colorectal cancer tissue and a significant drop in IgGFcBP expression in tumour cells.

All the results "validate the importance of core-fucosylated proteins profile analysis to understand the mechanisms which promote cancer onset and progression", the team explained in the report.

It is hoped that by identifying these proteins, scientists could potentially find new biomarkers or therapeutic targets.

Posted by Neil Clark


Digital Edition

Chromatography Today - Buyers' Guide 2022

October 2023

In This Edition Modern & Practical Applications - Accelerating ADC Development with Mass Spectrometry - Implementing High-Resolution Ion Mobility into Peptide Mapping Workflows Chromatogr...

View all digital editions

Events

NGVS 2024

May 23 2024 Beijing, China

Analiza

May 28 2024 Tel Aviv, Israel

HTC-18

May 28 2024 Leuven, Belgium

PREP 2024

May 28 2024 Philadelphia, PA, USA

CISILE 2024

May 29 2024 Beijing, China

View all events