Electrophoretic Separations
Electrophoretic fluorescence used to seek melanoma biomarkers
Sep 03 2010
Researchers from Tianjin Medical University and Tianjen Children's Hospital in China explain in the Journal of Experimental & Clinical Cancer Research that high incidences of malignant melanoma have created a need for more detailed understanding of melanoma metastasis.
This, they write, is the most formidable problem in a form of neoplasm that continues to occur at a high worldwide incidence rate.
Using electrophoresis, they were able to use fluorescence of cyanine dyes to study multiple samples in a single two-dimensional gel.
They identified vimentin, a cytoskeleton structural protein, as both a biomarker for melanoma and also as a clinical predictor for hematogenous metastasis.
The Journal of Experimental & Clinical Cancer Research is the official periodical of the Regina Elena National Cancer Institute, providing an online forum for oncology findings from clinical and translational work.
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