• Effect of MPA treatment studied
    Scientists have gained insight into MPA treatment

Electrophoretic Separations

Effect of MPA treatment studied

Sep 22 2011

Scientists have used quantitative analysis processes to identify the effect a therapeutic treatment has on kidney cells.

In a study, published by Proteome Science and undertaken by a team at University Medical Centre Goettingen, the scientists explained that mycophenolic acid (MPA) is a treatment commonly used as a post-transplantation medicine to prevent organ rejection.

By using quantitative analysis processes, the team sought to identify the proteome alterations in human embryonic kidney cells (HEK-293) after a dose of MPA.

A significant apoptosis was observed after MPA treatment, with the proliferation assay demonstrating that therapeutic MPA concentration causes a dose dependent inhibition of HEK-293 cell proliferation.

The expression of five proteins was down-regulated following the treatment, with the majority of the altered proteins linked to the cytoskeleton, chromatin structure/dynamics and energy production/conversion.

"Further characterisation of these proteins may help to understand the diverse cellular effects of MPA in addition to its immunosuppressive activity," the scientists concluded.

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