Analytical chemistry has allowed scientists to assess the involvement of STAT3 in inflammatory responses associated with neuropathological conditions.
Immunological response periodical the Journal of Neuroinflammation has published the findings of the research, which was conducted at the Third Military Medical University in China.
Using an electrophresis mobility shift assay, the researchers looked at the ability of STAT3 to bind to DNA as part of a study into signalling of the transcription factor in microglial activation induced by electromagnetic fields (EMF).
They found that the JAK2-STAT3 pathway is capable of promoting pro-inflammatory responses when microglial cells are stimulated by EMFs.
As a result, they suggest that the pathway could represent a therapeutic avenue for diminishing the pro-inflammatory effect.
The scientists explain that their research arises from the rapid proliferation of EMFs in the everyday living environment.
Sources of EMF activity include power lines, microwave emitters, radio transmitters and electronic devices, they note.
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