• 40-year-old phasing problem solved with computation

Electrophoretic Separations

40-year-old phasing problem solved with computation

Apr 25 2012

A 40-year-old phasing problem has been solved by scientists at the University of Warwick who have developed a computation which simultaneously doubles the resolution, sensitivity and mass accuracy of Fourier Transform Mass Spectrometry (FT-MS).

The findings have been published in the journal Analytical Chemistry, and could potentially lead to a significant reduction in laboratory costs. The breakthrough can be used in all  FT-MS including FT-ICR, Orbitrap and FT-TOF instruments. It will also have applications in proteomics, petroleum analysis, metabolomics and pharmaceutical analysis among other fields.

Professor Peter O’Connor, who co-developed the method, said: “We have vastly improved the quality of data available at no extra cost.”

“FTMS is used extensively in the fields of pharmaceuticals, healthcare, industry, natural resources and environmental management so this breakthrough represents a real step towards improving research across the board in these areas.”

Their study is entitled "Absorption-Mode: The Next Generation of Fourier Transform Mass Spectra", and has been published in the journal Analytical Chemistry. It is co-authored by Professor O’Connor, Yulin Qi, Mark Barrow and Huilin Li from the University of Warwick.

Posted by Neil Clark

Digital Edition

Chromatography Today - Buyers' Guide 2022

October 2023

In This Edition Modern & Practical Applications - Accelerating ADC Development with Mass Spectrometry - Implementing High-Resolution Ion Mobility into Peptide Mapping Workflows Chromatogr...

View all digital editions


MSB 2024

May 19 2024 Brno, Czech Republic

Water Expo Nigeria 2024

May 21 2024 Lagos, Nigeria

NGVS 2024

May 23 2024 Beijing, China


May 28 2024 Tel Aviv, Israel


May 28 2024 Leuven, Belgium

View all events