Valve Innovation Optimises Chromatography Process; Removing Dead Legs, Minimising Hold-Up Volumes & Increasing Yields

Dec 22 2009

Author: Brett Davies on behalf of Unassigned Independent Article

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There are a number of important considerations in the optimised design of a chromatography process; the selection of valves being not least amongst them. The importance of correct valve selection is evidenced by the benefits it provides. As well as delivering equipment and installation savings, optimised valve selection can eliminate all dead legs, meaning that sterility is easier to ensure and maintain. It can also mean faster flow shifts and reduced risk of cross contamination. In addition, the compact design of the latest single diaphragm valves, combined with manifold blocks, ensures minimal hold-up volumes, increasing product yields, with less media waste.

Typical challenges for valve solutions in chromatography: Valve selection is usually a crucial discussion point amongst design engineers, with traditional solutions generally based around diaphragm valve technologies. These solutions make use of very closely welded cluster arrangements, with the shortest possible tangents and optimised positioning according to draining/cleaning requirements. However, even with optimised design, the requirement for minimised hold-up volumes in complete chromatography systems can often be compromised by complex valve clusters. This is because, the more valves needed, the more welds, pipe lengths, Tpieces that are required, and, ultimately, the more hold- up volume generated....

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