• Biochemistry analyses mouse resistance to obesity
    Biochemistry research has indicated how mice may resist developing obesity


Biochemistry analyses mouse resistance to obesity

Feb 04 2011

Mechanisms that allow mice to resist developing obesity have been analysed using gel filtration chromatography by a team of French and Slovenian biochemistry and veterinary scientists.

Writing in BMC Genomics, an open-access, peer-reviewed periodical covering all aspects of genomic research, they explain how gel filtration chromatography allowed plasma lipoproteins to be investigated in their mouse test subjects.

Subsequent fast protein liquid chromatography further separated out the major lipoproteins from their samples, so that cholesterol distribution could be studied.

The team found HDL cholesterol, which protects against obesity, was elevated in the mice categorised as "lean" compared with those deemed to be "fat".

Higher HDL, accompanied by upregulation of synthesis of bile acids, may explain how cholesterol is excreted from lean mice, allowing them to avoid becoming obese, they suggest.

In their conclusion, the team write: "We identified novel candidate molecular targets and metabolic changes which can, at least in part, explain resistance to obesity development in the 'lean' line."

Digital Edition

Chromatography Today - Buyers' Guide 2022

December 2021

In This Edition Modern & Practocal Applications - Accelerating ADC Development with Mass Spectrometry - Implementing High-Resolution Ion Mobility into Peptide Mapping Workflows Chromatogr...

View all digital editions


Plastics Recycling World Expo Europe

Jun 14 2023 Essen, Germany

HPLC 2023

Jun 18 2023 Dusseldorf, Germany


Jul 04 2023 Cardiff, UK

Water Expo Nigeria 2023

Jul 11 2023 Lagos, Nigeria

ACS National Meeting & Expo, Fall 2023

Aug 13 2023 San Francisco, CA, USA

View all events