LC-MS in use to fingerprint PHY906
Aug 19 2010
PHY906 is effective at reducing gastrointestinal toxicity resulting from treatment with CPT-11, a chemotherapy drug also known as irinotecan, the researchers write in Science Translational Medicine.
The 1,800-year-old formulation is now the subject of LC-MS investigations to learn more about its structure, reports Nature.
Yung-Chi Cheng, a pharmacologist at Yale University who is working on the project, tells the news provider: "This is a new paradigm of drug development. It's a typical example of West meets East."
In their study, the scientists note how PHY906 is able to increase anti-tumour effects during treatment with CPT-11, while also reducing the amount of weight lost by the patient.
They add that the anti-toxicity effects witnessed occur simultaneously through a number of different mechanisms when the herbal medicine is administered to chemotherapy participants.
Chromatography Today - Buyers' Guide 2022
In This Edition Modern & Practocal Applications - Accelerating ADC Development with Mass Spectrometry - Implementing High-Resolution Ion Mobility into Peptide Mapping Workflows Chromatogr...
View all digital editions
ACS National Meeting & Expo, Spring 2023
Mar 26 2023 Indianapolis, IN, USA
Apr 18 2023 Kintex, South Korea
Apr 19 2023 Ho Chi Minh City, Vietnam
Apr 30 2023 Dublin, Ireland & Online
Apr 30 2023 Denver, CO, USA