• What is GC-MS Used For?


What is GC-MS Used For?

Feb 04 2022

GC-MS is one of the most well-known hyphenated chromatography techniques. That doesn’t quite mean it’s well-known universally though. In this post, we’ll look at GC-MS in more detail, including the many ways it’s used.

What is GC-MS?

GC-MS stands for gas chromatography mass spectrometry. It combines a gas chromatograph – which vapourises a sample into a gas phase and separates it into various components – with a mass spectrometer, which breaks components into ionised fragments. This allows them to be analysed separately for better identification and quantification.

As well as being used for non-specific testing of multiple components, GC-MS is highly useful as a specific test for identifying substances. Put simply, it can provide a 100% specific test to positively identify the presence of a particular substance.

Applications of GC-MS


GC-MS can be used to analyse samples taken from suspects to link them to a crime. That could be matching a blood sample to one found at the crime scene, for example.


The method is also renowned for its use analysing fire debris. GC-MS can confirm the presence of accelerants, giving investigators a better idea of how a fire was started.

Drug detection

Another use of GC-MS is determining which compounds are present in a human body using samples of blood or urine. That’s given rise to three more specific applications:

  • Illegal drugs – GC-MS can be used to detect illegal drugs, assisting the police with anti-drug law enforcement.
  • Doping – It can also be used by anti-doping laboratories to test athlete samples for performance-enhancing drugs.
  • Death – Finally, GC-MS can identify substances present in human bodies after death, providing a better idea of the cause of death or any foul play.


With the cost of GC-MS equipment falling and reliability on the up, the technique has also been adopted more widely as part of environmental studies. It can be used to detect the presence of pesticides, VOCs and other contaminants.


The application above also makes GC-MS useful for the analysis of food products, ensuring they’re not contaminated by pesticides, for example. On top of that, it is often used to analyse the composition of food and drink products, including flavour and aroma compounds that give them a distinctive profile.

An example of this is discussed in the article ‘Analysis and Identification of Mezcal and Tequila Aromas by Ambient Ionisation MS, GC-MS, and GCxGC-MS’.


Perhaps one of the most interesting applications of GC-MS is the analysis of samples from space programs. GC-MS has been used to analyse the atmosphere of Venus, along with samples taken from Mars and a Jupiter-family comet.

So, next time you’re watching a rocket launch, remember that GC-MS equipment could well be on board!

Digital Edition

Chromatography Today - Buyers' Guide 2022

December 2021

In This Edition Modern & Practocal Applications - Accelerating ADC Development with Mass Spectrometry - Implementing High-Resolution Ion Mobility into Peptide Mapping Workflows Chromatogr...

View all digital editions


ACS National Meeting & Expo, Spring 2023

Mar 26 2023 Indianapolis, IN, USA

Korea Lab 2023

Apr 18 2023 Kintex, South Korea

Analytica Vietnam

Apr 19 2023 Ho Chi Minh City, Vietnam

SETAC Europe

Apr 30 2023 Dublin, Ireland & Online

AOCS Annual Meeting & Expo

Apr 30 2023 Denver, CO, USA

View all events