Meeting Reports and Events

Oligonucleotides: The Next Big Challenge For Analytical Chemistry - George Okafo & Chris Bevan

Sep 13 2010

Author: George Okafo & Chris Bevan on behalf of Unassigned Independent Article

Free to read

This article has been unlocked and is ready to read.

Download

Research and development of oligonucleotides as therapeutic medicines is experiencing exponential growth and interest within academia, the biotechnology and pharmaceutical industries [1]. This has largely been driven
by several key historical events including:

1. The regulatory approval of the first antisense oligonucleotide (ASO) for cytomegalovirus infection Vitravene® (1998)[2],
2. Approval of Macugen®, an aptamer for treatment of wet macular degeneration (2005) [3]
3. The discovery by Drs Andrew Fire and Craig Mello of gene silencing by RNA interference (RNAi) (published 1998, Nobel Prize, 2006).[4]

RNAi technology has been used to validate gene targets, and both RNAi and ASO technologies have been used to interfere with targets that are considered non-druggable by traditional small molecule interventions [5]. The early Nobel Prize-winning work by Fire and Mello demonstrated that some genes in C.elegans can be switched off by the introduction of double stranded small interfering RNA (siRNA) to block the normal translation of a specific messenger RNA to the protein product [4]. This early identification of the process has been extended to mammalian cells and the molecular process characterized.

Free to read

This article has been unlocked and is ready to read.

Download


Digital Edition

Chromatography Today - Buyers' Guide 2022

December 2021

In This Edition Modern & Practocal Applications - Accelerating ADC Development with Mass Spectrometry - Implementing High-Resolution Ion Mobility into Peptide Mapping Workflows Chromatogr...

View all digital editions

Events

Dioxin 2022

Oct 09 2022 New Orleans, LA, USA

SPICA 2022

Oct 11 2022 Lisbon, Portugal

WWEM 2022

Oct 12 2022 Telford, UK

MicroTAS 2022

Oct 23 2022 Hangzhou, China & Virtual

Plastics Recycling World Expo North America

Nov 09 2022 Cleveland, OH, USA

View all events