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The use of countercurrent chromatography (CCC) as a preparative technique is seen to occupy a niche area of separation science and is largely used to isolate natural products. The technique has however considerable untapped potential both at the laboratory preparative scale and also at lar...
HPLC, UHPLC, LC-MS
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Introduction
Water Condensation Nucleation (or Water Condensation Particle Counting) is a technology originally developed to detect aerosol particles in the application field of environmental monitoring. Using this technique air was drawn through an instrument and any particles counted to...
HPLC, UHPLC, LC-MS
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Many liquid chromatography methods are developed using organic mobile phase additives which allow compatibility with mass-spectrometric (MS) detection. However, these types of additives often give high UV absorbance which can lead to low level impurity quantitation issues.
Additionally,...
HPLC, UHPLC, LC-MS
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A method was developed to analyse three model aminoglycosides (neomycin, apramycin, and kanamycin) using a zwitterionic HILIC (hydrophilic interaction liquid chromatography) stationary phase and mass spectrometry (MS) detection. High separation efficiency and good peak shape were obtained...
HPLC, UHPLC, LC-MS
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Today Hydrophilic Interaction Liquid Chromatography (HILIC) is by far the fastest growing HPLC separation mode, currently being used by almost 20% of the HPLC instrument owners [1], although the relative number of applications still is considerably fewer. Does this mean HILIC is yet anothe...
HPLC, UHPLC, LC-MS
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In developing new analytical instruments and in particular chromatography instrumentation there is a need to modify or manufacture components to perform experiments and initiate the innovation. Usually this means anything from ordering bespoke parts to fabricating components and devices in...
HPLC, UHPLC, LC-MS