Time Controlled Cryogenic Zone Compression (T-CZC): A Novel Gas Chromatographic Tool for Increasing Sensitivity
Feb 28 2012
Author: Dirk Krumwiede, Heinz Mehlmann, Kyle D’Silva on behalf of Thermo Fisher Scientific Chromatography and Mass Spectrometry
The analysis of semi-volatile trace contaminants represent a unique challenge to the analytical chemist. Modern techniques of gas chromatography and mass spectrometry have reduced instrumental limits of detection from the nanogram range in the 1970s, using packed chromatography columns and quadrupole mass spectrometry; to the low femtogram range during the twenty-first century, using capillary columns coupled to high resolution or tandem quadrupole mass spectrometers [1].
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