Due to their association with other biomolecules as well as their unique chemical properties, oligonucleotide therapeutics present unique challenges in their isolation and LC/MS analysis from biologic...
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Introduction
Anyone reviewing the hottest buzzwords in bioanalysis over the last few years could not escape the phrase ’Dry Blood Spot’ or DBS. The advantages of the technique have been tirelessly ch...
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It is established that for electrospray LC-MS(/MS) assays, co-eluting phospholipids may cause ion suppression which can lead to method inconsistency and reduced sensitivity [1, 2]. The abundance of ph...
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Bioanalysis has evolved considerably over the last ten years with the rapid implementation of three key technology levers: robotics for automated sample extraction, fast liquid chromatography coupled...
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Two major problems in biotherapeutics are aggregation of and the presence of variants of active pharmaceutical ingredients. These product-related substances can have different efficacy than the main p...
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The accurate determination of the concentration of a drug candidate and it’s resulting metabolites in biological fluids plays an essential in the drug discovery, preclinical and clinical development p...
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The use of atmospheric pressure ionisation (API) LC-MS/MS has been very successful in drug bioanalysis. Despite this, many challenges, such as those presented by (a) sample matrix and mobile phase eff...
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This is a pharmaceutical industry perspectiv of the way bioanalytical technologies are changing in response to the changing types of molecules under development and the regulatory drivers required to...
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