Gel permeation chromatography (GPC), also known as size exclusion chromatography (SEC) is a technique for obtaining information on the molecular weight distributions of polymers. After polymer type (c...
Read
The area of biomolecular characterisation for molecular weight determination has increased rapidly with the requirements for a complete picture of the behaviour of biomolecules in solution being both...
Read
About 5 years ago, [1] the particle size of packing media in HPLC columns was reduced to 2 µm or smaller. This new column technology named U-HPLC or UPLC offers much better resolution and column effic...
Read
Stimulated by the sustainability agenda, the polymer industry is actively engaged in developing new materials that combine excellent performance with low carbon footprint. Molecular weight is a defini...
Read
Soon after a very successful symposium on the ‘Essential Oils, Flavors and Fragrances’ in November 2010, Chromatographic Society of India (CSI) entered yet another exciting year of activities. It was...
Read
The introduction by several chromatography column manufacturers of sub-2 µm fully-porous as well as core-shell sub-3 µm UHPLC columns over the last several years have profoundly impacted the chromatog...
Read
A seminal paper was written by Manz et al.
(1) identifying the use of possibilities of using ‘chip based technology’ within an analytical instrument. When did you as a scientist first think that ‘chi...
Read
Monoclonal antibodies (mAbs) are an important class in the group of new biological entities with about 30 antibody drugs licensed for treatment of various diseases [1]. These glycoproteins bear comple...
Read
The advent of capillary and chip-based electrophoresis has opened up new possibilities for high-throughput analysis of a diversity of biological systems. The high-resolution separations typical of chi...
Read
We have all read about lab-on-a-chip (LOC) devices (or if we hadn’t already, we will now after reading this issue of Chromatography Today!) and how they may offer the possibility of miniaturising anal...
Read
A relatively new application for ionic liquids, as solvents in static Headspace Gas Chromatography, is further investigated. Two ionic liquids were studied and the response towards a range of low boil...
Read
Mixed-mode chromatography is emerging as a powerful tool in separation of various molecules. Mixed-mode is defined as liquid chromatography in which at least two modes of interactions exist simultaneo...
Read
As delegates weaved their way through leafy West Sussex on the morning of 11th May it was a bright sunny day. These were gloomy times though for R&D in major UK pharma but to all intents and purposes...
Read
There is growing environmental concern regarding the health impact of trace levels of pharmaceuticals and personal care products (PPCPs) in water resources. Although the term PPCP was only recently co...
Read
The use of countercurrent chromatography (CCC) as a preparative technique is seen to occupy a niche area of separation science and is largely used to isolate natural products. The technique has howeve...
Read