News Archive
Latest 50 news articles
New Diode Array Detector for LC
Agilent Technologies introduce the 1200 Infinity Series high dynamic range diode array detector for liquid chromatography. It delivers 30 times wider linear UV-range and up to 30 times higher sensitivity than previous detectors. Analyzing such samples usually requires additional sample preparation (dilution/concentration) and a second injection, sometimes with recalibration. The new Agilent 1200 Infinity Series detector eliminates these time-consuming efforts, acquiring all sample information in...
Partisil & Partisphere HPLC column range acquired by Hichrom
Hichrom Limited are pleased to announce the acquisition of the Partisil and Partisphere HPLC column consumable product line from Whatman, a division of GE Healthcare. Based in the UK, Hichrom are a leading European manufacturer and distributor of HPLC columns, consumables and media, with manufacturing facilities accredited to both ISO9001 (Quality) and ISO14001 (Environmental) standards. Hichrom have worked closely with GE Healthcare during the manufacture of these products for a number of years...
Phenomenex Introduces Aeris Core-Shell HPLC and UHPLC Technology for Proteins and Peptides
Phenomenex introduces Aeris™ – core-shell HPLC/UHPLC columns specially designed for the analysis of proteins and peptides. These new high-performance columns deliver higher resolution and peak capacities than other bioseparation media, producing sub-2 micron results on any LC instrument. With virtually no bleed, Aeris columns are highly compatible with MS. Aeris columns are offered in wide- and small-pore configurations. Aeris WIDEPORE 3.6-micron core-shell columns are optimized for the separat...
LC System Provides Powerful Capabilities for Separations Science
Agilent Technologies introduce the Agilent 1290 Infinity Quaternary LC system, the first quaternary UHPLC system to deliver the accuracy and precision of binary systems. The new Agilent 1290 Infinity Quaternary pump is the foundation of this new system. The pump offers a maximum pressure of 1200 bar. Features include active damping and exceptionally high-resolution pump drives, as well as Agilent's unique microfluidic technology in the new Inlet Weaver and newly designed Jet Weaver mixer. This h...
NEW UHPLC columns - for Alternative Selectivity
HALO, the ‘original’ Fused-Core UHPLC columns manufactured by Advanced Materials Technology, feature a 0.5µm porous silica layer ‘fused’ onto a 1.7µm solid silica particle. The resulting columns provide faster separations and higher sample throughput, without compromising column efficiency, ruggedness and reliability. HALO® Penta-HILIC is the latest addition to the range of original Fused-Core® columns for HPLC and UHPLC (ultra-fast) separations from Advanced Materials Technology. These Fused-Co...
Interactive Resource for Core-Shell HPLC / UHPLC Column Users
Phenomenex introduces the “Kinetex Experience” – an online center for the many tools available to users of the company’s flagship core-shell HPLC/UHPLC columns and those interested in learning about core-shell technology. Designed for users at all levels in all applications, the site includes technical and application information, the latest Kinetex calculator for easy method transfers, column selection tools, FAQs and online technical support. Phenomenex has also created a new “Core Club,” wher...
The 38th International Symposium on High Performance Liquid Phase Separations
The 38th International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2012) will be held on June 16-21, 2012 in Anaheim, California, USA. This year’s conference continues the tradition of visiting celebrated cities. Although HPLC Symposium has previously visited the West Coast of the United States– landing three times in San Francisco (1986, 1996, and 2006) and once in Seattle (2000) - it has never been held in Southern California. Thus, HPLC 2012 Anaheim ma...
Announcing the New Kromasil HILIC-D
Kromasil HILIC-D is designed for the best selectivity of polar compounds. Kromasil HILIC-D offers a column that is 100% MS compatible. The phase is low bleed and the solvents used when running your HPLC in HILIC mode are optimal for MS. Therefore the sensitivity can be 100 times better when using Kromasil HILIC-D over traditional RP columns. Traditionally, polar compounds like organic acids, nucleobases, and water soluble vitamins have been a challenge to separate on a standard reversed phase c...
Partisil® and Partisphere® HPLC column ranges acquired by Hichrom from Whatman/GE Healthcare
Hichrom Limited are pleased to announce the acquisition of the Partisil® and Partisphere® HPLC column consumable product line from Whatman, a division of GE Healthcare. Based in the UK, Hichrom are a leading European manufacturer and distributor of HPLC columns, consumables and media, with manufacturing facilities accredited to both ISO9001 (Quality) and ISO14001 (Environmental) standards. Hichrom have worked closely with GE Healthcare during the manufacture of these products for a number of ye...
Improve your LC productivity with NEW 2.5 eXtended Performance [XP] 2.5 µm Columns
eXtended Performance [XP] 2.5 µm Columns are high efficiency, low backpressure HPLC columns that can be easily utilised across all HPLC, UHPLC and UPLC Technology platforms. Rapid Method Optimisation Within Current Pharmacopeia Guidelines. • Transfer methods TODAY within current pharmacopeia guidelines • Utilise on an ACQUITY UPLC System to future-proof your method Low Backpressure. High throughput. Improved Productivity. • 40% lower backpressure than sub-2-µm UPLC Columns • Increase flow r...
NEW product brochure available for ACE® ExcelTM Ultra Robust UHPLC Columns – with high efficiency 2µm particles and unique phases for rapid method development
A new product brochure for ACE Excel UHPLC Columns is now available from Advanced Chromatography Technologies Limited. ACE Excel Ultra Robust UHPLC columns offer you all the benefits that chromatographers have come to expect from ACE columns (exceptional reproducibility and robustness, combined with excellent quality and efficiency) but have been especially engineered to withstand the demanding conditions of UHPLC. New High Efficiency 2µm ACE Particles - ACE Excel UHPLC columns are available in...
The Novel Triazole Bonded HILIC Column
NACALAI TESQUE (JAPAN) introduces COSMOSIL HILIC for hydrophilic interaction chromatography. This novel triazole bonded silica stationary phase provides higher polarity than non-modified silica columns, resulting in stronger hydrophilic interactions. The positively charged triazole stationary phase also offers an anion-exchange mechanism, enabling the strong retention of acidic compounds. The COSMOSIL HILIC Chromatogram Index, which includes 167 chromatograms using COSMOSIL HILIC, is available o...
Next-Generation Kinetex® Calculator Customizes Core-Shell HPLC/UHPLC Method Creation
Phenomenex, introduces the next-generation Kinetex Calculator - an online tool that generates customized, optimized Kinetex methods for HPLC or UHPLC systems. With user input, which is entered online, the Calculator quickly produces an optimized method based on the customer's own running conditions. The enhanced Calculator incorporates all six Kinetex phases, including the new phenyl-hexyl chemistry, and will calculate a new gradient program to account for differences in column dimensions and a...
Lonza launches new microbial-based platform
A new microbial-based platform for the production of high-quality plasmid DNA vaccines and therapeutics has been launched by Lonza. The pDNA platform consists of three harmonised processes; fermentation, primary recovery, and purification. It begins with a unique, fed batch, high cell density fermentation process compatible with multiple Escherichia coli (E. coli) host organisms, followed by noble primary recovery process performed under low shear conditions. A unique, two column purification pl...
Amino Acid Analysis - Easily Turn Any HPLC System into an Amino Acid Analyser with Pinnacle PCX
ARC Sciences Ltd offers Pickering Laboratories Pinnacle Post Column reactions systems, which are a complete solution to Amino Acid Analysis. We supply columns, eluants, reagents and post-column derivatisation instruments that work seamlessly with virtually any modern HPLC so we can guarantee the accuracy and reproducibility of the analysis. Pickering chemists will help choose the method and instrumentation best suited to your requirements, work with you on any custom method optimization and offe...
Counterfeiting is impacting malaria treatment
Criminal activity is responsible for poor quality vital anti-malarials in Africa. According to a team from Tanzania, treatment of plasmodium falciparum malaria is more difficult than it ought to be, as a key component of controlling the virus is having a high availability of good quality artemisinin-derivative based combination therapy (ACT) at the correct dose. The team, however, stated that reports from Africa suggest this is not being provided. Using high performance liquid chromatography...
XMRV is able to downregulate A3G
Quantitative analysis processes have been used to gain insight into the processes of a virus. Published in the Virology Journal, a team from the USA sought to investigate Xenotropic murine leukaemia virus (MLV)-related virus (XMRV), which is a gammaretrovirus discovered in prostate cancer tissues. The scientists hypothesised that XMRV is a laboratory contaminant and may have originated via a rare recombination event, but suggested that APOBEC3G (A3G) could restrict its replication. Using west...
MS/MS used in cancer study
Scientists have used tandem affinity purification and mass spectrometry (MS/MS) processes to investigate the relationship between Snail and hepatocellular carcinoma (HCC). In a Korea-based study published by the BMC Biology journal, the team noted that HCC is a common and highly invasive malignant tumour which can quite often be fatal. The scientists explained that the aberrant expression of Snail via activation of reactive oxygen species increases the invasive nature of HCC but they sought to d...
Scientists improve LC-MS/MS processes
Scientists have used liquid chromatography-tandem mass spectrometry (LC-MS/MS) to determine the level of benzophenone in food and drink. In a study published by Rapid Communications in Mass Spectrometry, a team from the University of Barcelona and Thermo Fisher Scientific, explained that the EU has set a specific migration limit for benzophenone of 600 µg/L in liquids such as milk and fruit juices, and there is an official toxicological tolerable daily intake. However, it is difficult to test...
Unison UK-Amino, a highly stable, high resolution amino packing for the use in Anion Exchange and Normal Phase Applications.
Unison UK-Amino is a 3µm particle size, polymer coated silica, with the Amino Ligand bonded using a proprietary method and offers exceptional durability, even in highly aqueous mobile phases. As well as being exceptionally stable the phase can be packed to very high efficiencies, and shows very high resolution of both saccharides and oligosaccharides. Unison UK-Amino has been used for both sugar analysis in foodstuffs as well as glycobiology. The use of simple water:acetonitrile mobile phases ma...
Easy to tailor UHPLC system delivers throughput productivity gains to maximize ROI
Shimadzu UK is introducing its next-generation Nexera UHPLC system which is a flexible modular chromatography solution packed full of ultra-high performance benefits including open access, the lowest carryover, highest pressure rating, shortest autosampler cycle time and the highest injection volume precision. The new Nexera UHPLC system ensures fully reliable ultra-high speed and ultra-high resolution analysis across an extensive number of application fields by offering an innovative mix of pre...
HPLC to UPLC Method Conversion Services Introduced
Waters Corporation announce that its customer Advantar Laboratories, Inc. has successfully completed its rollout of Waters® Empower 3 Chromatography Software. The 21CFR Part 11 compliant-ready software will play a key role at Advantar and with its new Method Remediation Services group to meet increased demand by pharmaceutical and contract manufacturing customers for converting legacy HPLC methods to Ultra Performance LC® (UPLC®) methods, which offer greater speed, resolution and sensitivity....
New HPLC Columns for Ion-Exchange Chromatography
NACALAI TESQUE introduces COSMOGEL IEX Series for Ion-Exchange Chromatography. Ion-Exchange Chromatography (IEX) has been widely used for the analysis and purification of biomolecules such as proteins, peptides and polynucleotides. COSMOGEL IEX Series is available in amphoteric ion-exchange type, in which two kinds of packing materials are mixed, as well as in widely used anion-exchange type and cation-exchange type. The amphoteric ion-exchange type enables the simultaneous separation of both...
NEW range of Robust UHPLC Columns launched
ACE® ExcelTM Ultra Robust UHPLC columns offer you all the benefits that chromatographers have come to expect from ACE columns (exceptional reproducibility and robustness, combined with excellent quality and efficiency) but have been especially engineered to withstand the demanding conditions of UHPLC. Additionally, ACE® ExcelTM UHPLC columns are available in a wide range of selectivities, including the unique ACE C18-AR and ACE C18-PFP phases, enabling chromatographers to take advantage of the e...
LCMS used in bovine study
Quantitative analysis processes have been used to investigate the role the NarQP two-component signal transduction system plays in response to the presence of nitrate for the bovine pathogen Mannheimia haemolytica A1. A team from the University of Guelph in Canada explained that M.haemolytica A1 is normally found in the upper respiratory tract of healthy calves, according to the BMC Research Notes report. However, it is an opportunistic pathogen that can lead to bovine respiratory disease comp...
Lightweight, Compact Digital Liquid Flow Meter for Any HPLC Pump
Featuring a single chip microcontroller and accurate to ± 1% of calibrated flow rates the lightweight 12-ounce FlowCal 5000 HPLC liquid flowmeter available from Tovatech supports FDA compliance for IQ, OQ and PQ validations on any HPLC pump. The highly accurate FlowCal 5000 HPLC Flow Meter According to Tovatech Director Dr. Robert Sandor, "the FlowCal 5000 liquid flow meter is faster and more accurate than using timers while manually collecting fluid for gravimetric or volumetric measurement i...
LC supplements can decrease fatty livers
Scientists have used high-performance liquid chromatography (HPLC) processes to determine the effect, both preventive and therapeutic, of L-carnitine (LC) on non-alcoholic fatty liver disease (NAFLD) in streptozotocin (STZ)-induced type 2 diabetic mice. In a study published by Diabetology &Metabolic Syndrome, a team from the Center for Human Functional Experiment in China sought to gain insight into why there are an increasing number of patients suffering from fatty liver caused by type 2 diabet...
LC-MS/MS used in biofuel study
Scientists have used liquid chromatography-mass spectrometry tandem mass spectrometry (LC-MS/MS) to gain further insight into the enzymatic repertoire involved in plant polysaccharide degradation by the lower termite C. gestroi. A team from the Laboratorio Nacional de Ciencia e Tecnologia do Bioetanol in Brazil hoped that they could learn more about lignocellulosic materials, as they have recently been highlighted as a sustainable resource for the biofuel industry, however the production of biof...
Algorithm created for LC-MS datasets
Scientists have created an algorithm to aid the analysis of multiple liquid chromatography-mass spectrometry (LC-MS) datasets. Researchers from the Department of Electrical and Computer Engineering at the University of Texas at San Antonio, USA, suggested that identifying corresponding features, such as LC peaks registered by identical peptides, plays a crucial role in the analysis of peptides and protein mixtures so more needs to be done to enhance the efficiency of the process. In a study publ...
Analysis of dormant terminal buds of poplar trees
A series of mass spectrometry processes have been used to shed light on the proteins involved in the dormant terminal buds of poplar trees. The team from the State Key Laboratory of Forest Genetics and Tree Breeding in China explained that while there has been considerable progress in identifying the molecular mechanisms involved in bud dormancy of woody plants, little is known about the roles of protein phosphorylation. In a study published by BMC Plant Biology, the scientists used mass spectro...
American ginseng could inhibit colon cancer development
A study has been conducted to determine if American ginseng could be used to inhibit the development of colon cancer in people who consume a western diet. The research aimed to decipher if ginseng could inhibit western diet promoted colonic tumorigenesis and if compound K, a microbial metabolite of ginseng, could suppress colon cancer xenograft growth. Mice were initiated with azoxymethane (AOM) and were fed a western diet, containing 20 per cent fat, or a western diet supplemented with 250-ppm...
NEW Ultra Robust UHPLC Columns – 2µm, 3µm and 5µm particle sizes and unique selectivities for rapid method development
ACE® ExcelTM Ultra Robust UHPLC columns offer you all the benefits that chromatographers have come to expect from ACE columns (exceptional reproducibility and robustness, combined with excellent quality and efficiency) but have been especially engineered to withstand the demanding conditions of UHPLC. Additionally, ACE® ExcelTM UHPLC columns are available in a wide range of selectivities, including the unique ACE C18-AR and ACE C18-PFP phases, enabling chromatographers to take advantage of the e...
New HPLC/UHPLC Technology for Proteins and Peptides
Phenomenex Inc., introduces Aeris - core-shell HPLC/UHPLC columns specially designed for the analysis of proteins and peptides. These new high-performance columns deliver higher resolution and peak capacities than other bioseparation media, producing sub-2 micron results on any LC instrument. With virtually no bleed, Aeris columns are highly compatible with MS. Aeris columns are offered in wide- and small-pore configurations. Aeris WIDEPORE 3.6-micron core-shell columns are optimized for the...
Nano-UHPLC System Significantly Increases Productivity During Proteomics Research at the University of Southern Denmark
Thermo Fisher Scientific announce that the Center for Experimental Bioinformatics (CEBI) at the University of Southern Denmark is using Thermo Scientific nano-ultra high performance liquid chromatography (UHPLC) technology to accelerate productivity and improve efficiencies during its proteomics research. Implementation of the Thermo Scientific EASY-nLC 1000 has enabled 34 percent more peptide and 22 percent more protein identifications within the CEBI laboratory, significantly increasing produc...
New MS process created
Scientists have created a new mass spectrometry (MS) process that for the first time ever will allow for the absolute quantification of proteins from Plasmodium falciparum. In a study published by the Malaria Journal and undertaken by a team from the UK, the scientists noted that Plasmodium falciparum is a protozoan parasite and one of the species of Plasmodium that is known to cause severe malaria in humans. The team undertook the process which involved "selected reaction monitoring MS ... comb...
ACQUITY UPLC FROM WATERS
One of the most significant developments in separations science in the past decade has been the introduction of Ultra Performance Liquid Chromatography, known as UPLC®. UPLC® Technology, which has been adopted successfully in laboratories around the world for the most demanding separations, is a highly robust, dependable, and reproducible system. What differentiates the system’s holistic design is Waters’ patented sub-2-μm hybrid particle chemistry, which offers significant benefits over tod...
Find your Application on Our Chromatography Resource Center - Benefit from Our Experience
Finding information on how to resource and run new chromatography applications can often be a daunting task. Thermo Fisher Scientific has a wealth of technical and experimental experience for you to explore. The comprehensive Chromatography Resource Center (CRC) is a reference guide to meet all your separation needs. What’s New and What’s Hot? Our experts present their work and research at conferences year round. The CRC contains access to data which is presented at these leading scientific mee...
NEW ACE® Excel™ Ultra Robust UHPLC Columns – 2µm, 3µm and 5µm particle sizes and unique selectivities for rapid method development
Advanced Chromatography Technologies have launched a new range of UHPLC columns. ACE® Excel™ Ultra Robust UHPLC columns offer you all the benefits that chromatographers have come to expect from ACE columns (exceptional reproducibility and robustness, combined with excellent quality and efficiency) but have been especially engineered to withstand the demanding conditions of UHPLC. Additionally, ACE® Excel™ UHPLC columns are available in a wide range of selectivities, including the unique ACE C18-...
NEW Sugar Analysis Application Note describing developments in HPLC-Pulsed Amperometric Detection - Superior Sensitivity, Robustness and Stabilisation time
The analysis of Carbohydrates by Pulsed Amperometric Detection (PAD) is recognised as the one of the most sensitive and "universal" methods of analysing mixtures of carbohydrates. A new application note from Antec demonstrates the sensitivity, ease of use and robust operation of the Decade II SCC Pulsed Amperometric Detector. The stabilisation time for the Decade II is around an hour and not the day or days often encountered for PADs to settle. For monosaccharides, concentration limits of detect...
LCMS used in prenatal alcohol study
Scientists have used liquid chromatography tandem mass spectrometry (LC-MS/MS) to measure the neuroprotective effects of activity-dependent neurotrophic factor (ADNF-9) against alcohol-induced apoptosis using TUNEL staining. In a study published by the Journal of Biomedical Science, scientists from the US aimed to investigate the role of ADNF-9 against ethanol teratogenesis during early foetal brain development using LC-MS/MS. The team exposed six pregnant mice from embryonic days seven to 13 to...
LCMS used in lipopolysaccharide investigation
Liquid chromatography mass spectrometry (LCMS) has been used in an investigation into lipopolysaccharide-induced inflammation and additive inhibitory effect of cefmetazole. In a study published by journal Fluids and Barriers of the CNS, scientists from the Graduate School of Medicine and Pharmaceutical Sciences in Japan sought to examine the effect of lipopolysaccharide (LPS)-induced inflammation on cerebral prostaglandin E2 (PGE2) elimination from the brain, and whether antibiotics further inhi...
Whole proteome studied with 2D-LC-MS/MS
Liquid chromatography mass spectrometry processes have been used to investigate ABE fermentation between glucose and xylose substrates.In a study published by Proteome Science and undertaken by scientists at McGill University in Quebec, a team sought to examine the shotgun proteomic profiling of C.acetobutylicum from ABE fermentation using glucose and xylose to understand the functional mechanisms of C.acetobutylicum proteins involved in butanol production.The scientists identified 894 different...
HLPC used in tobramycin study
Scientists have used quantitative analysis processes to determine the presence of tobramycin in blood and urine during selective decontamination of the digestive tract in critically ill patients.In a study published by Critical Care, a team from the Netherlands noted that tobramycin is one of the components used for selective decontamination of the digestive tract (SDD), applied to prevent colonisation and subsequent infections in critically ill patients.Tobramycin is not normally absorbed into...
Chromatography Videos Bring Technology to the Desktop
Thermo Fisher Scientific highlights its wide range of technical chromatography videos, available to watch on the Thermo Scientific Chromatography Resource Center (CRC). Giving instant access to the chromatography experience and expertise of Thermo Fisher Scientific, these videos contain updates and technical explanations of topical issues in HPLC, GC and SPE. The full portfolio of presentations, hosted on the Chromatography videos channel, is accessible to view via the CRC homepage. With 6000...
''Agilent Technologies’ LC/MS Manufacturing Achieves ISO 13485 Certification''
Agilent Technologies announce that its liquid chromatography/mass spectrometry systems, including 6100 Series single quadrupole and 6400 Series triple quadrupole systems, are now manufactured under ISO 13485 certification. This is an internationally recognized standard of quality management for the design and manufacture of medical devices. “This is just the latest step that Agilent has taken to clear the way for use of our life science tools in the clinic,” said Gustavo Salem, Agilent vice pr...
Scientists test water for steroids
Scientists have used liquid chromatography tandem mass spectrometry (LC-MS/MS) to determine the extent to which environmental waters have been contaminated with pharmaceutical products.A study published by the Chemistry Central Journal and undertaken by a team from the School of Pharmacy and Chemistry at Kingston University, London, noted that the frequent use of a wide range of drugs meant that various environmental waters have been found to be contaminated with pharmacologically active substan...
''Eksigent Chip Column Family expanded for Nano and Micro LC Proteomics Analysis''
AB SCIEX, announced the extension of its Eksigent line of column chips for the cHiPLC®-nanoflex system. Five new chips were introduced expanding the flexibility and application of the system for high-performance proteomics analysis including biomarker discovery, validation and verification. The extended offering adds higher flow micro cHiPLC columns for peptide separation at increased throughput levels, as well as new phases for the analysis of intact proteins, phosphopeptides and glycans. A...
UHPLC Column life extended
Phenomenex introduces SecurityGuard ULTRA, a protection system that extends UHPLC column life. An extension of the Phenomenex SecurityGuard line, the new ULTRA is ideal for virtually any manufacturer’s UHPLC, sub-2-micron or core-shell columns including the Phenomenex Kinetex® products. SecurityGuard ULTRA protects against the damaging effects of chemical contaminants and microparticulates introduced by the sample, mobile phase or system, which can negatively impact column lifetime, method se...
''New Online Vial Selection Tool launched''
Phenomenex introduces the Verex™ Vial Finder – an online tool for quickly selecting the right vial from among hundreds of Phenomenex certified products. The easy-to-use tool empowers the user to quickly zero in on the best vial and cap for the appropriate application. All Phenomenex Verex vials are lot-tested and certified to exceed industry specifications and tolerances for cleanliness and consistent performance. The high-purity, chemically stable borosilicate glass offers pH stability and th...
Sample Preparation Portfolio expanded
Thermo Fisher Scientific introduce the Thermo Scientific HyperSep SLE chromatographic sample preparation option for processing and simplifying extraction of samples from complex biological matrices. The new sample preparation format offers a fast, effective method to reduce sample background and concentrate the desired analytes. The HyperSep™ SLE technology gives greater reproducibility and reliability in sample preparation compared to Liquid/Liquid Extraction (LLE). And, unlike protein precipi...